20 November 2017 - Can health care databases be used to confirm a supplemental indication that has been demonstrated in a randomised clinical trial for an approved medication?
This cohort study replicated the results of a randomised clinical trial that established the supplemental indication for telmisartan by using data from a US health care database (insurance claims data) available at the time that the supplemental indication was approved. Similar to the randomised clinical trial, our study revealed a decreased risk of angioedema with telmisartan compared with ramipril.